GenePage for the ftsW gene of Escherichia coli K-12

Primary Gene Name: ftsW
EcoGene Accession Number: EG10344
K-12 Gene Accession Number: ECK0090
MG1655 Gene Identifier: b0089
Gene Name Mnemonic: Filamentation, temperature sensitive
Alternate Gene Symbols: None
Description: Putative lipid II flippase; divisome protein recruiting FtsI; SEDS protein
  # bp Upstream # bp Downstream
MW: 45987.09 ---------414 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 98403
Left Intergenic Region

Name: murD_ftsW

Length: 1 bp overlap

Orientation: Codirectional+

Left_end: 98403

Right_end: 98403

Centisome: 2.12

Genomic Address
Minute or Centisome (%) = 2.12
Right End: 99647
Right Intergenic Region

Name: ftsW_murG

Length: 4 bp overlap

Orientation: Codirectional+

Left_end: 99644

Right_end: 99647

Centisome: 2.15

Inactivation of MurJ in vivo, but not FtsW, blocks lipid II translocation (Sham, 2014). Overproduced FtsW but not overproduced MurJ increases lipid II translocation across the cytoplasmic membrane in crude reconstituted vesicles (Mohammadi, 2011). Both FtsW and MurJ are involved in lipid II translocation but which one is the actual flippase is controversial with conflicting in vivo and in vitro results; the in vitro results utilize crude membrane vesicles that also contain MurJ, which may not be limiting; the in vivo results do not demonstrate flippase activity directly and FtsW inactivation could be incomplete, so one of the two proteins could be stimulating the other which has the flippase activity; MurJ is related to known flippase exporters and FtsW is not, suggesting that MurJ may indeed be the actual flippase (Young, 2014). FtsW faciltates septal petidoglycan synthesis by recruiting the cognate FtsI transpeptidase. FtsW is required for mrdA(PBP2) expression. ftsW is paralogous to mrdB(rodA). ftsW is an essential gene. Divisome protein. FtsN has been shown by FRET to directly interact with itself, FtsW, FtsI and ZapA (Alexeeva, 2010).

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