GenePage for the hipA gene of Escherichia coli K-12

Primary Gene Name: hipA
EcoGene Accession Number: EG10443
K-12 Gene Accession Number: ECK1500
MG1655 Gene Identifier: b1507
Gene Name Mnemonic: High persistence
Alternate Gene Symbols: None
Description: Inactivating GltX kinase facilitating persister formation; toxin of HipAB TA pair; autokinase
  # bp Upstream # bp Downstream
MW: 49275.82 ---------440 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1590854
Left Intergenic Region

Name: yneL_hipA

Length: 317 bp gap

Orientation: Codirectional-

Left_end: 1590537

Right_end: 1590853

Centisome: 34.27

Genomic Address
Counterclockwise
Minute or Centisome (%) = 34.27
Right End: 1592176
Right Intergenic Region

Name: hipA_hipB

Length: 1 bp overlap

Orientation: Codirectional-

Left_end: 1592176

Right_end: 1592176

Centisome: 34.30

HipA is not EF-Tu kinase; HipA phosphorylates and inactivates GltX (glutamate--tRNA ligase) on active site residue Thr239, causing RelA-dependent ppGpp synthesis and inducing multidrug tolerance and persistence (Germain, 2013). HipA binds and was reported to phosphylate TufA/TufB residue Thr-383 in vitro (Schumacher, 2009). HipA serine protein kinase autophosphorylates Ser150 and this activity is essential for persister formation (Correia, 2006).

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BamHI EcoRI HindIII