GenePage for the dinD gene of Escherichia coli K-12

Primary Gene Name: dinD
EcoGene Accession Number: EG11193
K-12 Gene Accession Number: ECK3635
MG1655 Gene Identifier: b3645
Gene Name Mnemonic: Damage inducible
Alternate Gene Symbols: orfY; pcsA; yicD
Description: DNA-damage-inducible protein, function unknown
  # bp Upstream # bp Downstream
MW: 31078.16 ---------274 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3817760
Left Intergenic Region

Name: yicC_dinD

Length: 220 bp gap

Orientation: Codirectional+

Left_end: 3817540

Right_end: 3817759

Centisome: 82.25

Genomic Address
Clockwise
Minute or Centisome (%) = 82.25
Right End: 3818584
Right Intergenic Region

Name: dinD_yicG

Length: 289 bp gap

Orientation: Codirectional+

Left_end: 3818585

Right_end: 3818873

Centisome: 82.27

Null mutants of dinD(pcsA,orfY) are viable in normal growth conditions (Poulsen, 1989; Ohmori, 1995). dinB and pcsA are allelic (Lewis, 1994; Lundegaard, 1994; Ohmori, 1995). A dinD68(pcsA68) point mutant (V239M) has a cold-sensitive growth phenotype, forming filaments with large nucleoids, that is suppressible by recA or lexA mutations (Ohmori, 1995). The cold-sensitive growth phenotype of dinD68(pcsA68)-cs is multi-copy suppressible by lexA, dinG and dinI (Yasuda, 1996). A deletion of dinD(pcsA,orfY) forms filaments and has a reduced plating efficiency on kanamycin in rich medium at late stationary phase, and exhibits growth defects at 45C; these phenotypes were exacerbated in a yicC(orfX) dinD(pcsA,orfY) double mutant; a yicC(orfX) single mutant was not tested (Poulsen, 1991). LexA regulon.

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BamHI EcoRI HindIII