GenePage for the glnD gene of Escherichia coli K-12

Primary Gene Name: glnD
EcoGene Accession Number: EG11411
K-12 Gene Accession Number: ECK0165
MG1655 Gene Identifier: b0167
Gene Name Mnemonic: Glutamine
Alternate Gene Symbols: None
Description: Bifunctional uridylyltransferase/uridylyl-removing enzyme; (UTase/UR); controls uridylylation state and activity of PII(GlnB)
  # bp Upstream # bp Downstream
MW: 102390.14 ---------890 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 185978
Left Intergenic Region

Name: dapD_glnD

Length: 30 bp gap

Orientation: Codirectional-

Left_end: 185948

Right_end: 185977

Centisome: 4.01

Genomic Address
Counterclockwise
Minute or Centisome (%) = 4.01
Right End: 188650
Right Intergenic Region

Name: glnD_map

Length: 61 bp gap

Orientation: Codirectional-

Left_end: 188651

Right_end: 188711

Centisome: 4.06

GlnD has both a uridylyltransferase and a uridylyl-removing activity. The only known substrates for GlnD are the two PII proteins GlnB and GlnK. In both cases GlnD covalently modifies residue Tyr51 in the T-loop of the substrate thereby controlling the ability of GlnB and GlnK to interact with their specific targets. The activity of GlnD is controlled by the intracellular glutamine availability. Glutamine inhibits the transferase action of GlnD and as a consequence GlnB and GlnK are deuridylylated in N-sufficient conditions. [Comment provided by EcoTeam member Mike Merrick, 11.16.06]

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BamHI EcoRI HindIII