GenePage for the argK gene of Escherichia coli K-12

Primary Gene Name: argK
EcoGene Accession Number: EG11445
K-12 Gene Accession Number: ECK2914
MG1655 Gene Identifier: b2918
Gene Name Mnemonic: Arginine
Alternate Gene Symbols: meaB; scpK?; ygfD
Description: Required to convert succinate to propionate, Arg transport?; reported to have ATPase and protein kinase activity
  # bp Upstream # bp Downstream
MW: 36703.92 ---------331 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3062987
Left Intergenic Region

Name: scpA_argK

Length: 8 bp overlap

Orientation: Codirectional+

Left_end: 3062987

Right_end: 3062994

Centisome: 65.99

Genomic Address
Clockwise
Minute or Centisome (%) = 65.99
Right End: 3063982
Right Intergenic Region

Name: argK_scpB

Length: 10 bp gap

Orientation: Codirectional+

Left_end: 3063983

Right_end: 3063992

Centisome: 66.01

The role of ArgK in arginine transport needs to be reexamined. Characterization of the ArgK ortholog MeaB strongly suggests that ArgK is actually involved in protecting Mcm from inactivation and that ArgK may bind to Mcm. MeaB and Mcm are fused in some organisms. MeaB of M. extorquens binds and hydrolyzes GTP. ArgK is a homolog of the human disease gene MMAA, implicated in methylmalonic aciduria. argK is part of a four gene operon encoding enzymes converting succinate to propionate. ATPase, but not protein kinase, activity is reportedly required for arginine transport. ArgK does not have predicted transmembrane segments typical of a membrane protein.

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BamHI EcoRI HindIII