GenePage for the hinT gene of Escherichia coli K-12

Primary Gene Name: hinT
EcoGene Accession Number: EG12172
K-12 Gene Accession Number: ECK1089
MG1655 Gene Identifier: b1103
Gene Name Mnemonic: HIstidine triad nucleotide-binding
Alternate Gene Symbols: ycfF
Description: Activator of DadA, D-alanine catabolism; purine nucleoside phosphoramidase; aminoacyl-adenylate hydrolase
  # bp Upstream # bp Downstream
MW: 13241.28 ---------119 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1161885
Left Intergenic Region

Name: fhuE_hinT

Length: 333 bp gap

Orientation: Divergent

Left_end: 1161552

Right_end: 1161884

Centisome: 25.02

Genomic Address
Clockwise
Minute or Centisome (%) = 25.03
Right End: 1162244
Right Intergenic Region

Name: hinT_ycfL

Length: 2 bp gap

Orientation: Codirectional+

Left_end: 1162245

Right_end: 1162246

Centisome: 25.04

A hinT mutant cannot catabolize D-alanine due to a defect in DadA dehydrogenase preventing D-alanine utilization; the role of HinT is post-transcriptional and requires both the enzymatic activity and the C-terminal domain (Bardaweel, 2011). HinT hydrolyzes lysyl-AMP, an activity that may be involved in the regulation of translation or the scavanging of aminoacyl-adenylates (Chou, 2006). hinT is essential for growth under high salt conditions (Chou, 2005). HinT is a member of the HIT (histidine triad) family that contains Ap3A and Ap4A hydrolases. HinT is a low abundance protein.

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BamHI EcoRI HindIII