GenePage for the glnK gene of Escherichia coli K-12

Primary Gene Name: glnK
EcoGene Accession Number: EG12191
K-12 Gene Accession Number: ECK0444
MG1655 Gene Identifier: b0450
Gene Name Mnemonic: Glutamine
Alternate Gene Symbols: ybaI
Description: Potent activator of NRII(GlnL/NtrB) phosphatase; trimeric; regulated through NRI/NRII two-component regulatory system; binds to membrane when inhibiting AmtB
  # bp Upstream # bp Downstream
MW: 12259.22 ---------112 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 472598
Left Intergenic Region

Name: mdlB_glnK

Length: 180 bp gap

Orientation: Codirectional+

Left_end: 472418

Right_end: 472597

Centisome: 10.18

Genomic Address
Clockwise
Minute or Centisome (%) = 10.18
Right End: 472936
Right Intergenic Region

Name: glnK_amtB

Length: 29 bp gap

Orientation: Codirectional+

Left_end: 472937

Right_end: 472965

Centisome: 10.19

glnK is a glnB paralog. Like GlnB, the GlnK protein is a member of the trimeric PII signal transduction protein family. In nitrogen limitation it is subject to post-translational modification by uridylylation (mediated by GlnD) of Tyr51 in the T-loop of each subunit. This modification is reversed in N-sufficient conditions. In ammonium sufficient conditions non-uridylylated GlnK forms a 1:1 complex with the ammonia channel protein AmtB and prevents ammonium uptake through AmtB. Complex formation is reversed by ammonium starvation. [Comment provided by EcoTeam member Mike Merrick, 11.16.06]

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BamHI EcoRI HindIII