GenePage for the arsB gene of Escherichia coli K-12

Primary Gene Name: arsB
EcoGene Accession Number: EG12236
K-12 Gene Accession Number: ECK3487
MG1655 Gene Identifier: b3502
Gene Name Mnemonic: Arsenate resistance
Alternate Gene Symbols: arsF
Description: Arsenite pump, inner membrane; resistance to arsenate, arsenite, and antimonite
  # bp Upstream # bp Downstream
MW: 45497.45 ---------429 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3648935
Left Intergenic Region

Name: arsR_arsB

Length: 53 bp gap

Orientation: Codirectional+

Left_end: 3648882

Right_end: 3648934

Centisome: 78.61

Genomic Address
Clockwise
Minute or Centisome (%) = 78.61
Right End: 3650224
Right Intergenic Region

Name: arsB_arsC

Length: 12 bp gap

Orientation: Codirectional+

Left_end: 3650225

Right_end: 3650236

Centisome: 78.64

ArsB can function alone using PMF to drive transport, as is the case with the chromosomal ArsB, which lacks the ArsA ATPase; ArsB proteins can use ATP to drive efflux if ArsA is present. The chromosomal ArsB is listed in TCDB as one of two 3.4.A.1.1 proteins; the TC 3.4.A.1.1 ArsA protein is plasmid-derived. The correct TC class for the stand-alone E. coli chromsomal ArsB is 2.A.45 and the ArsB protein should probably be re-classified as TC 2.A.45.1.2. IT (Ion Transporter) superfamily (Prakash, 2003). ST(3) structural class based on hydropathy profile (Lolkema, 2003).

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BamHI EcoRI HindIII