GenePage for the bcsZ gene of Escherichia coli K-12

Primary Gene Name: bcsZ
EcoGene Accession Number: EG12258
K-12 Gene Accession Number: ECK3516
MG1655 Gene Identifier: b3531
Gene Name Mnemonic: Bacterial cellulose synthesis
Alternate Gene Symbols: bcsC; yhjM
Description: Endo-1,4-D-glucanase; breaks down carboxymethylcellulose; periplasmic cellulase
  # bp Upstream # bp Downstream
MW: 41700.28 ---------368 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3689155
Left Intergenic Region

Name: bcsC_bcsZ

Length: 19 bp overlap

Orientation: Codirectional-

Left_end: 3689155

Right_end: 3689173

Centisome: 79.48

Genomic Address
Minute or Centisome (%) = 79.48
Right End: 3690261
Right Intergenic Region

Name: bcsZ_bcsB

Length: 6 bp gap

Orientation: Codirectional-

Left_end: 3690262

Right_end: 3690267

Centisome: 79.50

The bcsQ' domestication in-frame stop codon pseudogene defect in K-12 strain W3110 has been repaired, restoring cellulose production, colony morphology, biofilm architecture, and the divergent bcs operons' functions to a presumably wildtype status (Serra, 2013). The first 21 aa of BcsZ are predicted to be a type I signal peptide. Probable false positive lipoprotein prediction; a soluble periplasmic BcsZ protein is predicted. The presence of an in-frame stop codon mutation in the bcsQ' gene abolishes cellulose production and bcs divergent operon function in E. coli K-12.

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