GenePage for the acnB gene of Escherichia coli K-12

Primary Gene Name: acnB
EcoGene Accession Number: EG12316
K-12 Gene Accession Number: ECK0117
MG1655 Gene Identifier: b0118
Gene Name Mnemonic: Aconitase
Alternate Gene Symbols: yacI; yacJ
Description: Aconitate hydratase 2; aconitase B; 2-methyl-cis-aconitate hydratase; iron-sulfur cluster; monomeric
  # bp Upstream # bp Downstream
Verified Start MW: 93498.11 ---------865 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 131615
Left Intergenic Region

Name: yacH_acnB

Length: 354 bp gap

Orientation: Divergent

Left_end: 131261

Right_end: 131614

Centisome: 2.83

Genomic Address
Clockwise
Minute or Centisome (%) = 2.84
Right End: 134212
Right Intergenic Region

Name: acnB_yacL

Length: 175 bp gap

Orientation: Codirectional+

Left_end: 134213

Right_end: 134387

Centisome: 2.89

AcnB is the major catabolic aconitase interconverting citrate and iso-citrate via cis-aconitate during exponential growth (Cunningham, 1997). During oxidative stress inactive AcnB apo-enzyme without iron sulphur clusters binds the acnB mRNA 3' UTR, stabilizes acnB mRNA and increases AcnB synthesis, thus mediating a post-transcriptional positive autoregulatory switch (Tang, 1999). AcnB contains a 4Fe-4S cluster that requires either IscA or SufA for proper assembly (Tan, 2009). AcnB is required for the oxidation of propionate to pyruvate and for growth on propionate due to its 2-methyl-cis-aconitate hydratase activity (Brock, 2002). Binds TrxA (Kumar, 2004).

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BamHI EcoRI HindIII