GenePage for the dauA gene of Escherichia coli K-12

Primary Gene Name: dauA
EcoGene Accession Number: EG12392
K-12 Gene Accession Number: ECK1194
MG1655 Gene Identifier: b1206
Gene Name Mnemonic: Dicarboxylic acid uptake
Alternate Gene Symbols: ychM
Description: C4-dicarboxylic acid transporter at low pH; STAS domain
  # bp Upstream # bp Downstream
MW: 59429.05 ---------559 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1259124
Left Intergenic Region

Name: ychH_dauA

Length: 54 bp gap

Orientation: Convergent

Left_end: 1259070

Right_end: 1259123

Centisome: 27.13

Genomic Address
Counterclockwise
Minute or Centisome (%) = 27.13
Right End: 1260803
Right Intergenic Region

Name: dauA_prs

Length: 124 bp gap

Orientation: Codirectional-

Left_end: 1260804

Right_end: 1260927

Centisome: 27.16

DauA is a C4-dicarboxylic acid transporter with a STAS domain that may be a dicarboxylic acid sensor; DauA is primarily responsible for succinate and fumarate transport at pH 5; dauA mutants have lowered DctA activity at pH 7; previous reports suggesting DauA(YchM) may be a bicarbonate transporter were disputed as no DauA-dependent bicarbonate accumulation could be detected; the substrate specificity of DctA and DauA differ (Karinou, 2012). dauA(ychM) mutants are synthetic lethal with fabBDHGAI, are alkali-sensitive, and appear to have impaired bicarbonate incorporation in the presence of NaCl; DauA(YchM) co-purifies with fatty acid metabolism enzymes; (Babu, 2010). Induced during biofilm formation.

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BamHI EcoRI HindIII