GenePage for the gadC gene of Escherichia coli K-12

Primary Gene Name: gadC
EcoGene Accession Number: EG12456
K-12 Gene Accession Number: ECK1486
MG1655 Gene Identifier: b1492
Gene Name Mnemonic: Glutamic acid decarboxylase
Alternate Gene Symbols: acsA; xasA
Description: Glutamate-GABA antiporter; glutamate-dependent enzyme, may function in protection against cytoplasmic acidification
  # bp Upstream # bp Downstream
MW: 55076.67 ---------511 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1568954
Left Intergenic Region

Name: yddW_gadC

Length: 130 bp gap

Orientation: Codirectional-

Left_end: 1568824

Right_end: 1568953

Centisome: 33.80

Genomic Address
Counterclockwise
Minute or Centisome (%) = 33.80
Right End: 1570489
Right Intergenic Region

Name: gadC_gadB

Length: 155 bp gap

Orientation: Codirectional-

Left_end: 1570490

Right_end: 1570644

Centisome: 33.83

GlsA and GadC form an acid resistance system sufficient to protect E. coli from acid stress in the pressence of glutamine (Lu, 2013). The crystal structure and functional characterization of the E. coli O157:H7 glutamate-gamma-aminobutyric acid antiporter GadC was determined and is identical in sequence to the K-12 enzyme (Ma, 2012). EvgAS regulon.

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BamHI EcoRI HindIII