GenePage for the hypT gene of Escherichia coli K-12

Primary Gene Name: hypT
EcoGene Accession Number: EG12566
K-12 Gene Accession Number: ECK4318
MG1655 Gene Identifier: b4327
Gene Name Mnemonic: Hypochlorite-responsive transcription factor
Alternate Gene Symbols: qseD; yjiE
Description: Hypochlorite-responsive transcription factor
  # bp Upstream # bp Downstream
MW: 34710.72 ---------303 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 4557378
Left Intergenic Region

Name: iraD_hypT

Length: 8 bp overlap

Orientation: Convergent

Left_end: 4557378

Right_end: 4557385

Centisome: 98.18

Genomic Address
Counterclockwise
Minute or Centisome (%) = 98.18
Right End: 4558289
Right Intergenic Region

Name: hypT_iadA

Length: 64 bp gap

Orientation: Codirectional-

Left_end: 4558290

Right_end: 4558353

Centisome: 98.20

Three HypT(YjiE) methionine residues are converted to methionine sulfoxides by HOCl, activating HypT as a transcription factor; MsrA and MsrB inactivate HypT (Dazic, 2013). hypT(yjiE) mutants are sensitive to HOCl and yjiE plasmids confer HOCl resistance (Gebendorfer, 2012). HypT(YjiE) is a global regulator responding to HOCl exposure that replenishes methionine and cysteine pools and down-regulates genes involved in iron acquisition (Gebendorfer, 2012). HypT(YjiE) forms a variety of oligomers including dimers, tetramers and hexamers (Gebendorfer, 2012). The identification of YjiE as a motility regulator has been challenged as subsequently no effects of HypT(YjiE) on motility were observed (Gebendorfer, 2012). HypT(YjiE) is a LysR-type transcriptional regulator. HypT(YjiE) was initially identified as a cell density-dependent motility repressor.

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BamHI EcoRI HindIII