GenePage for the ibaG gene of Escherichia coli K-12

Primary Gene Name: ibaG
EcoGene Accession Number: EG12796
K-12 Gene Accession Number: ECK3179
MG1655 Gene Identifier: b3190
Gene Name Mnemonic: Influenced By Acid Gene
Alternate Gene Symbols: yrbA
Description: Acid stress protein; predicted transcriptional regulator, BolA family; low abundance protein
  # bp Upstream # bp Downstream
MW: 9451.74 ---------84 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 3336549
Left Intergenic Region

Name: murA_ibaG

Length: 54 bp gap

Orientation: Codirectional-

Left_end: 3336495

Right_end: 3336548

Centisome: 71.88

Genomic Address
Counterclockwise
Minute or Centisome (%) = 71.88
Right End: 3336803
Right Intergenic Region

Name: ibaG_mlaB

Length: 159 bp gap

Orientation: Codirectional-

Left_end: 3336804

Right_end: 3336962

Centisome: 71.89

A ibaG(yrbA) mutant is sensitive to acid stress; ibaG(yrbA) transcription is induced by acid stress; overexpression of IbaG(YrbA) improves acid resistance (Guinote, 2012). Overexpression of ibaG(yrbA), which is paralogous to the morphogene bolA, is toxic; an insertion in the upstream gene mlaB(yrbB) can be deleterious due to increased expression of ibaG(yrbA), which is why the non-essential mlaB(yrbB) gene does not have a kan insertion in the Keio collection (Malinverni, 2009). grxD mutations are synthetic lethal with mutations in the isc operon, suggesting that Grx4 is involved in an alternative FeS cluster assembly pathway; a similar synthetic lethality pattern was observed for the bolA-like gene ibaG(yrbA), but not for bolA (Butland, 2005).

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BamHI EcoRI HindIII