GenePage for the cof gene of Escherichia coli K-12

Primary Gene Name: cof
EcoGene Accession Number: EG13216
K-12 Gene Accession Number: ECK0440
MG1655 Gene Identifier: b0446
Gene Name Mnemonic: Complementation of fur
Alternate Gene Symbols: None
Description: HMP-PP phosphatase; catalyzes hydrolysis of 4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate (HMP-PP); MeO-HMP-PP and CF3-HMP-PP also serve as substrates for Cof; HAD18
  # bp Upstream # bp Downstream
MW: 30370.91 ---------272 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 467412
Left Intergenic Region

Name: ybaE_cof

Length: 99 bp gap

Orientation: Divergent

Left_end: 467313

Right_end: 467411

Centisome: 10.07

Genomic Address
Clockwise
Minute or Centisome (%) = 10.07
Right End: 468230
Right Intergenic Region

Name: cof_ybaO

Length: 152 bp gap

Orientation: Codirectional+

Left_end: 468231

Right_end: 468382

Centisome: 10.09

Cloned cof complements fur deletion mutant for growth on succinate: this gene name and function have only been reported as an annotation in EMBL entry Z54355, Patzer, S.I. and Hantke, K., 1995. HAD superfamily. Additional substrates include: pyridoxal phosphate (PLP), FMN, 2-deoxyglucose-6-P; in vitro activities demonstrated by Kuznetsova et al. (2005, 2006).

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BamHI EcoRI HindIII