GenePage for the cbtA gene of Escherichia coli K-12

Primary Gene Name: cbtA
EcoGene Accession Number: EG13389
K-12 Gene Accession Number: ECK1998
MG1655 Gene Identifier: b2005
Gene Name Mnemonic: Cytoskeleton Binding Toxin
Alternate Gene Symbols: yeeV
Description: Cytoskeleton binding toxin; toxin component of toxin-antitoxin protein pair CbtA-CbeA; CP4-44 putative defective prophage
  # bp Upstream # bp Downstream
MW: 13898.94 ---------124 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2077569
Left Intergenic Region

Name: cbeA_cbtA

Length: 88 bp gap

Orientation: Codirectional+

Left_end: 2077481

Right_end: 2077568

Centisome: 44.76

Genomic Address
Clockwise
Minute or Centisome (%) = 44.76
Right End: 2077943
Right Intergenic Region

Name: cbtA_yeeW

Length: 4 bp overlap

Orientation: Codirectional+

Left_end: 2077940

Right_end: 2077943

Centisome: 44.77

CbtA binds to and inhibits the polymerization of cytoskeletal proteins FtsZ and MreB; CbtA inhibits the GTPase activity of FtsZ (Tan, 2011). ykfI, ypjF and cbtA(yeeV) are paralogs. Overexpression of CbtA(YeeV) inhibits growth (Brown, 2003).

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BamHI EcoRI HindIII