GenePage for the csgG gene of Escherichia coli K-12

Primary Gene Name: csgG
EcoGene Accession Number: EG13413
K-12 Gene Accession Number: ECK1023
MG1655 Gene Identifier: b1037
Gene Name Mnemonic: Curlin sigma S-dependent growth
Alternate Gene Symbols: agfG(S.t.)
Description: Pore-forming OM lipoprotein for curli subunit secretion; CsgEFG curlin secretion complex
  # bp Upstream # bp Downstream
MW: 30557.14 ---------277 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1100851
Left Intergenic Region

Name: ycdZ_csgG

Length: 63 bp gap

Orientation: Convergent

Left_end: 1100788

Right_end: 1100850

Centisome: 23.72

Genomic Address
Counterclockwise
Minute or Centisome (%) = 23.72
Right End: 1101684
Right Intergenic Region

Name: csgG_csgF

Length: 26 bp gap

Orientation: Codirectional-

Left_end: 1101685

Right_end: 1101710

Centisome: 23.73

CsgG is the pore-forming subunit of the CsgEFG outer membrane secretion complex for exporting CsgA and CsgB; the first 20 amino acids of the mature CsgA curlin (residues 21-40) are sufficient to target heterologous proteins the the CsgEFG secretion complex (Robinson, 2006). CsgG alone can form outer membrane pores when over-expressed that lack specificity and directionality, leaking out small periplasmic proteins and making cells sensitive (permeable) to external erythromycin; co-expresssion of CsgE with CsgG produces curlin-specific export channels that require a 22 amino acid OM secretion signal from CsgA or, presuambly, CsgB for secretion; CsgE binds to and prevents the premature subunit assembly of curlin CsgA into amyloid fibers (Neninger, 2011). Overexpression causes abnormal biofilm architecture. The first 15 aa of CsgG are a type II signal peptide.

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BamHI EcoRI HindIII