GenePage for the flhE gene of Escherichia coli K-12

Primary Gene Name: flhE
EcoGene Accession Number: EG14013
K-12 Gene Accession Number: ECK1879
MG1655 Gene Identifier: b1878
Gene Name Mnemonic: Flagella
Alternate Gene Symbols: None
Description: Proton seal during flagellar secretion; periplasmic; bound to flagellar basal body; required for full swarming motility
  # bp Upstream # bp Downstream
MW: 14059.41 ---------130 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 1962580
Left Intergenic Region

Name: yecT_flhE

Length: 119 bp gap

Orientation: Convergent

Left_end: 1962461

Right_end: 1962579

Centisome: 42.28

Genomic Address
Counterclockwise
Minute or Centisome (%) = 42.28
Right End: 1962972
Right Intergenic Region

Name: flhE_flhA

Length: 1 bp overlap

Orientation: Codirectional-

Left_end: 1962972

Right_end: 1962972

Centisome: 42.29

E. coli flhE mutant cells grow slowly, are impaired for swarming motility, show filament-dependent cell lysis, and have lower cytoplasmic pH, consistent with a plug or chaperone function for FlhE to prevent protons from leaking into the cell during flagellar secretion (Lee, 2012). The first 16 aa are predicted to be a type I signal peptide; FlhE signal peptide cleavage, periplasmic localization, and basal body association was determined in Salmonella (Lee, 2012).

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BamHI EcoRI HindIII