GenePage for the bepA gene of Escherichia coli K-12

Primary Gene Name: bepA
EcoGene Accession Number: EG14199
K-12 Gene Accession Number: ECK2490
MG1655 Gene Identifier: b2494
Gene Name Mnemonic: beta-Barrel assembly-Enhancing Protease
Alternate Gene Symbols: yfgC
Description: Periplasmic metalloprotease and chaperone; outer membrane protein maintenance and assembly
  # bp Upstream # bp Downstream
MW: 53907.92 ---------487 aa Pre-Run BlastP UniProt
Pre-Run BlastP NR+Env
Left End: 2616094
Left Intergenic Region

Name: yfgO_bepA

Length: 212 bp gap

Orientation: Divergent

Left_end: 2615882

Right_end: 2616093

Centisome: 56.36

Genomic Address
Clockwise
Minute or Centisome (%) = 56.36
Right End: 2617557
Right Intergenic Region

Name: bepA_yfgD

Length: 20 bp gap

Orientation: Codirectional+

Left_end: 2617558

Right_end: 2617577

Centisome: 56.39

BepA(YfgC) is an EDTA-sensitive protease involved in the degradation of misfolded outer membrane proteins BamA and LptD; BepA is required for proper disulfide bond isomerization of LptD; a BepA protease active site mutant loses protease activity but retains partial LptD refolding activity; BepA binds BamA, possibly through its C-terminal TPR repeats, and this may be responsible for the membrane association of a portion of soluble periplasmic BepA (Narita, 2013). LoiP(YggG) interacts with the periplasmic metalloprotease/chaperone BepA(YfgC) required for the OM attachment of LoiP(YggG) (L├╝tticke, 2012). BepA(YfgC) is a TPR-repeats-containing protein of the M48 protease family; BepA(YfgC) has four tandem TPR (tetratricopeptide repeat) domains at residues 309 to 460. A bepA(yfgC) mutant has increased sensitivity to several antibiotics (Girgis, 2009). Overexpression of BepA(YfgC)causes abnormal biofilm architecture. The first 27 residues of BepA are predicted to be a type I signal peptide. Gene disruption does not cause growth defect, unpublished data Y. Akiyama cited in (Sakoh, 2005). htpX, loiP(yggG), bepA(yfgC) and ycaL are paralogs. RpoE regulon.

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BamHI EcoRI HindIII